Nasopharyngeal carcinoma (NPC) is endemic in East Asians, North Africans, their diasporas and the Inuit of Greenland and Canada. Radiologically it is first identified as asymmetry of the Fossa of Rosenmüller (FoR) in the nasopharynx. This asymmetry is also readily displayed on the cone-beam computed tomography (CBCT), as reflected in the outcomes of recent research, performed in Canada and Korea. This research is based around Takasugi et al’s three patterns of FoR observed on multi-detector CT (MDCT). These patterns varied in prevalence between the sexes, which in part may explain the higher prevalence of NPC in males. The nasopharynx is prominently displayed on medium-to-large fields-of-view (FOV) CBCT, because the pharynx of the vertically-positioned patient displayed on the CBCT hangs more openly than when the patient is lying supine for a MDCT. Although a minority of CBCTs display asymmetry of the FoR that will be easily visible to dentists, it is necessary to avoid undue referral of these cases as many may be false positives and could overwhelm already overworked specialist services. Therefore, care should also be taken with regards to the clinical history and examination of the neck, especially for lymphadenopathy. Finally, attention needs to paid to the velopharynx in such medium-to-large FOV CBCTs, which is immediately inferior to the nasopharynx., as this may reveal paragangliomas. These were just recently all pronounced malignant by the World Health Organization (WHO).